CHILLICOTHE, Ohio. U.S. Paper Mill has announced plans to transform the former Pixelle Specialty Solutions plant in Chillicothe into a regional hub for advanced manufacturing, aerospace innovation, medical device production and next-generation computing technologies. The redevelopment includes a major new partnership that brings high-performance computing infrastructure to the Ross County site, directly addressing questions from local viewers about whether this means a data center is coming to southern Ohio.
Yes. Through a collaboration with Aligned focused on advanced AMD hardware and technology, U.S. Paper Mill plans to develop a high-performance computing campus on the property. This represents an anticipated $1.5 billion investment and would establish the campus as a strategic hub for artificial intelligence infrastructure, advanced computing and next-generation technology jobs. U.S. Paper Mill will also expand its own fabrication operations to manufacture modular AI pods that support enterprise artificial intelligence computing and data processing.
Key Computing and Data Infrastructure Elements
• Partnership with Aligned to build a high-performance computing campus using advanced AMD technology.
• Anticipated $1.5 billion investment to create infrastructure for artificial intelligence and advanced computing.
• On-site production of modular AI pods by U.S. Paper Mill to support enterprise AI computing and data processing.
• Overall campus positioning as a hub for next-generation computing technologies alongside manufacturing.
These steps expand the site’s role beyond its current medical glove operations into advanced data infrastructure for the AI economy.
Other Partnerships and Job Creation
Additional agreements position the campus for broader growth. Amphibian Aerospace Industries will establish the United States’ first transport category amphibious aircraft fuselage and component manufacturing facility here. At full production, this is expected to create 150 to 200 direct advanced manufacturing jobs, more than 500 indirect jobs and over $400 million in annual revenue, with phase one investment up to $50 million.
U.S. Medical Glove Company continues its supply and licensing agreement, supporting approximately 150 onsite jobs. The gloves have already received Transportation Security Administration approval. U.S. Box Company is collaborating on research and development that could support a return of large-scale manufacturing.
Earlier this year, amid social media speculation about data center possibilities at the site, Heritage Headlines reached out to U.S. Paper Mill officials. Company representatives at that time reaffirmed the active focus on domestic medical glove production, which had already brought approximately 150 jobs following the facility’s acquisition in late 2025. The latest announcement builds on that foundation with expanded high-tech partnerships.
Regional Impact for Ross County and Southern Ohio
U.S. Sen. Bernie Moreno welcomed the progress. “Positive momentum continues for the great people of Chillicothe,” he said. “I made a promise to the community that I would not stop fighting for every single former paper mill employee until they have an opportunity for a job that pays them at least as much as they made before. I’m grateful for the hard work of U.S. Paper Mill to continue growing.”
Former U.S. Ambassador Robin Bernstein, a partner at U.S. Paper Mill, added that the effort brings “to life a bold vision for high-paying, high-skilled American jobs that can transform this historic facility into a new regional hub of innovation, production and opportunity.”
